| Autor: |
Sakashita, Chizuko, Saito, Takako, Kurosu, Tetsuya, Yoshinaga, Haruhiko, Kumagai, Takasi, Yamamoto, Koh, Miki, Tohru, Koyama, Takatoshi, Miura, Osamu, Nemoto, Tetsuo, Asakawa, Hideo, Hirosawa, Shinsaku |
| Předmět: |
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| Zdroj: |
British Journal of Haematology; Aug98, Vol. 102 Issue 3, p791-794, 4p, 2 Black and White Photographs |
| Abstrakt: |
We describe a case of Waldenström's macroglobulinaemia with two M-components (IgM and IgG) with the same λ light chain. Southern blot analysis of bone marrow cells showed rearrangements of immunoglobulin heavy and λ light chain genes. Sequencing of the complementarity determining region 3 of the two γ and μ transcripts showed 100% homology. Immunofluorescence study showed that most cells stained for both IgG and IgM. These findings indicated that a single population of cells was expressing two isotypic variants of IgG and IgM, as the genes responsible for production of both components had the same origin. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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Plný text