| Autor: |
Nakata, Bunzo, Amano, Ryosuke, Nakao, Shigetomi, Tamura, Tatsuro, Shinto, Osamu, Hirakawa, Toshiki, Okita, Yoshihiro, Yamada, Nobuya, Hirakawa, Kosei |
| Předmět: |
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| Zdroj: |
Journal of Experimental & Clinical Cancer Research (17569966); 2010, Vol. 29, p15-21, 7p |
| Abstrakt: |
Background: The combination of gemcitabine (GEM) and S-1, an oral 5-fluorouracil (5-FU) derivative, has been shown to be a promising regimen for patients with unresectable pancreatic cancer. Methods: Six patients with advanced pancreatic cancer were enrolled in this pharmacokinetics (PK) study. These patients were treated by oral administration of S-1 30 mg/m2 twice daily for 28 consecutive days, followed by a 14-day rest period and intravenous administration of GEM 800 mg/m2 on days 1, 15 and 29 of each course. The PK parameters of GEM and/or 5-FU after GEM single-administration, S-1 single-administration, and co-administration of GEM with pre-administration of S-1 at 2-h intervals were analyzed. Results: The maximum concentration (Cmax), the area under the curve from the drug administration to the infinite time (AUCinf), and the elimination half-life (T1/2) of GEM were not significantly different between GEM administration with and without S-1. The Cmax, AUCinf, T1/2, and the time required to reach Cmax (Tmax) were not significantly different between S-1 administration with and without GEM. Conclusion: There were no interactions between GEM and S-1 regarding plasma PK of GEM and 5-FU. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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