| Autor: |
Rabian, Claire, Tschöpe, Inga, Lesprit, Philippe, Katlama, Christine, Molina, Jean-Michel, Meynard, Jean-Luc, Delfraissy, Jean-François, Chêne, Geneviève, Lévy, Yves |
| Předmět: |
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| Zdroj: |
Clinical Infectious Diseases; 4/15/2010, Vol. 50 Issue 8, p1174-1183, 10p |
| Abstrakt: |
Background. The French National Agency for AIDS and Viral Hepatitis Research (ANRS) 114 Pneumovac trial showed that a strategy combining a 7-valent pneumococcal conjugate vaccine (PCV) prime at week 0 followed by a 23-valent pneumococcal polysaccharide vaccine (PPV) boost at week 4 enhances the frequency and magnitude of immunoglobulin (Ig) G responses against Streptococcus pneumoniae polysaccharides (SPPs) compared with PPV alone. CD4 T cell responses specific to the diphtheria-derived carrier protein CRM197 were evaluated. Methods. Lymphocyte proliferative responses (LPRs) and TH1 cytokine T cell responses against the diphtheriaderived carrier protein CRM197 contained in the PCV were investigated at weeks 0, 4, and 24. Results. In the prime-boost PCV and PPV group, the magnitude of LPRs to diphtheria toxoid and CRM197 increased at week 4 (P < .001) and persisted until week 24 (P = .08 and .13, respectively, compared with week 4). Interferon-γ and interleukin-2 production to CRM197 increased significantly at week 4 (P = .02 and P < .001, respectively) and remained stable until week 24 (P = .28 and P = .08, respectively). No changes were detected in the PPV group. A strong association among the magnitude of LPRs to CRM197 at week 4, the breadth of SPP specific IgG responses at week 8 (P = .03), and sustained IgG responses at week 24 was observed. A high frequency of helper follicular CD4+CXCR5+ T cells at baseline was associated with a better LPR response to CRM197. Conclusions. The PCV prime-elicited memory T cell responses were associated with better and sustained humoral SPP specific IgG responses. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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