| Autor: |
Shen-Orr, Shai S., Tibshirani, Robert, Khatri, Purvesh, Bodian, Dale L,, Staedtler, Frank, Perry, Nicholas M,, Hastie, Trevor, Sarwal, Minnie M,, Davis, Mark M,, Butte, Atul J. |
| Předmět: |
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| Zdroj: |
Nature Methods; Apr2010, Vol. 7 Issue 4, p287-289, 3p, 1 Diagram, 2 Graphs |
| Abstrakt: |
We describe cell type–specific significance analysis of microarrays (csSAM) for analyzing differential gene expression for each cell type in a biological sample from microarray data and relative cell-type frequencies. First, we validated csSAM with predesigned mixtures and then applied it to whole-blood gene expression datasets from stable post-transplant kidney transplant recipients and those experiencing acute transplant rejection, which revealed hundreds of differentially expressed genes that were otherwise undetectable. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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