| Autor: |
Roberts, Darren L., Dive, Caroline, Renehan, Andrew G. |
| Předmět: |
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| Zdroj: |
Annual Review of Medicine; 2010, Vol. 61 Issue 1, p301-316, 16p |
| Abstrakt: |
Body mass index, as an approximation of body adiposity, is associated with increased risk of several common and less common malignancies in a sexand site-specific manner. These findings implicate sexand cancer site-specific biological mechanisms underpinning these associations, and it is unlikely that there is a "one system fits all" mechanism. Three main candidate systems have been proposed-insulin and the insulin-like growth factor-I axis, sex steroids, and adipokines-but there are shortfalls to these hypotheses. In this review, three novel candidate mechanisms are proposed: obesity-induced hypoxia, shared genetic susceptibility, and migrating adipose stromal cells. While public health policies aimed at curbing the underlying causes of the obesity epidemic are being implemented, there is a parallel need to better understand the biological processes linking obesity and cancer as a prerequisite to the development of new approaches to prevention and treatment. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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