Crystal structure of the catalytic domain of human tumor necrosis factor-...-converting enzyme.

Autor: Maskos, Klaus, Fernandez-Catalan, Carlos, Huber, Robert, Bourenkov, Gleb P., Bartunik, Hans, Ellestad, George A., Reddy, Pranitha, Wolfson, Martin F., Rauch, Charles T., Castner, Beverly J., Davis, Raymond, Clarke, Howard R.G., Petersen, Melissa, Fitzner, Jeffrey N., Cerretti, Douglas Pat, March, Carl J., Paxton, Raymond J., Black, Roy A., Bode, Wolfram
Předmět:
Zdroj: Proceedings of the National Academy of Sciences of the United States of America; 03/31/98, Vol. 95 Issue 7, p3408, 5p, 8 Color Photographs, 1 Diagram
Abstrakt: Presents a study of the tumor necrosis factor-alpha (TNF alpha), which is a cytokine that induces protective inflammatory reactions and kills tumor cells but also causes severe damage when produced in excess, as in rheumatoid arthritis and septic shock. Materials and methods used; How TNF alpha is synthesized; Results and discussion.
Databáze: Complementary Index