A rare Asian founder polymorphism of Raptor may explain the high prevalence of Moyamoya disease among East Asians and its low prevalence among Caucasians.

Autor: Wanyang Liu, Hashikata, Hirokuni, Inoue, Kayoko, Matsuura, Norio, Mineharu, Yohei, Kobayashi, Hatasu, Kikuta, Ken-ichiro, Takagi, Yasushi, Hitomi, Toshiaki, Krischek, Boris, Li-Ping Zou, Fang Fang, Herzig, Roman, Jeong-Eun Kim, Hyun-Seung Kang, Chang-Wan Oh, Tregouet, David-Alexandre, Hashimoto, Nobuo, Koizumi, Akio
Zdroj: Environmental Health & Preventive Medicine; 2010, Vol. 15 Issue 2, p94-104, 11p, 2 Charts, 2 Graphs
Abstrakt: The article presents a study which investigated the potential of ss161110142 polymorphism of Raptor to explain the low prevalence of Moyamoya disease (MMD) among Caucasians and its high prevalence among East Asians. The linkage analysis and fine mapping were used in order to achieve the desired results of the study. The study found that the rare allele was more frequent in cases than in controls among Asian populations and was associated with an increase odds ratio of 52.2.
Databáze: Complementary Index
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