| Autor: |
Codd, Veryan, Mangino, Massimo, van der Harst, Pim, Braund, Peter S., Kaiser, Michael, Beveridge, Alan J., Rafelt, Suzanne, Moore, Jasbir, Nelson, Chris, Soranzo, Nicole, Guangju Zhai, Valdes, Ana M., Blackburn, Hannah, Leach, Irene Mateo, de Boer, Rudolf A., Goodall, Alison H., Ouwehand, Willem, van Veldhuisen, Dirk J., van Gilst, Wiek H., Navis, Gerjan |
| Předmět: |
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| Zdroj: |
Nature Genetics; Mar2010, Vol. 42 Issue 3, p197-199, 3p, 1 Chart, 1 Graph |
| Abstrakt: |
We conducted genome-wide association analyses of mean leukocyte telomere length in 2,917 individuals, with follow-up replication in 9,492 individuals. We identified an association with telomere length on 3q26 (rs12696304, combined P = 3.72 × 10−14) at a locus that includes TERC, which encodes the telomerase RNA component. Each copy of the minor allele of rs12696304 was associated with an ∼75-base-pair reduction in mean telomere length, equivalent to ∼3.6 years of age-related telomere-length attrition. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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