| Autor: |
Kataoka, Yasuro, Iwasaki, Tsuyoshi, Kuroiwa, Takanori, Seto, Yoshifumi, Iwata, Nobuo, Hashimoto, Naoaki, Ogata, Atsushi, Hamano, Teruaki, Kakishita, Eizo |
| Předmět: |
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| Zdroj: |
Immunology; Jul2001, Vol. 103 Issue 3, p310-318, 9p, 1 Black and White Photograph, 6 Graphs |
| Abstrakt: |
Summary Donor T cells are crucial for target organ injury in graft-versus-host disease (GVHD). We examined the effects of donor T cells on the target organs using a parent-into-F1 model of acute and chronic GVHD. Donor T cells showed engraftment in the spleen, small intestine and liver of mice with acute GVHD, causing typical GVHD pathology in these organs. Interferon-γ and Fas ligand expression were up-regulated, and host lymphocytes were depleted in the target organs of these mice. In contrast, donor T cells did not show engraftment in the small intestine of mice with chronic GVHD, and no GVHD pathology was observed in this organ. However, both donor T-cell engraftment and GVHD pathology were observed in the spleen and liver of chronic GVHD mice, along with the up-regulation of interleukin-4 (IL-4) and IL-10 expression plus the expansion of host lymphocytes such as splenic B cells and hepatic natural killer (NK) 1.1+ T cells. Donor anti-host cytotoxic T-lymphocyte activity was observed in spleen cells from mice with acute GVHD, but not in spleen cells from mice with chronic GVHD. Transplantation of Fas ligand-deficient (gld) spleen cells did not induce host lymphocyte depletion in target organs. These results indicate that donor T cells augment type 1 T helper immune responses and deplete the host lymphocytes from target organs mainly by Fas-mediated pathways in acute GVHD, while donor T cells augment type 2 T helper immune responses and expand host splenic B cells and hepatic NK1.1+ T cells in chronic GVHD. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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