| Autor: |
Minhong Yan, Callahan, Christopher A., Beyer, Joseph C., Allamneni, Krishna P., Gu Zhang, Ridgway, John Brady, Niessen, Kyle, Plowman, Greg D. |
| Předmět: |
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| Zdroj: |
Nature; 2/11/2010, Vol. 463 Issue 7282, pE6-E7, 2p, 1 Color Photograph, 1 Graph |
| Abstrakt: |
Arising from: J. Ridgway et al. 444, 1083–1087 (2006)Delta-like 4 (DLL4)-mediated Notch signalling has emerged as an attractive target for cancer therapy. However, the potential side effects of blocking this pathway remain uncertain. Here we show that chronic DLL4 blockade causes pathological activation of endothelial cells, disrupts normal organ homeostasis and induces vascular tumours, raising important safety concerns. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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