| Autor: |
de Sousa Luis, José Alixandre, Filho, José Maria Barbosa, Lira, Bruno Freitas, Medeiros, Isac Almeida, de Morais, Liana Clébia Soares Lima, dos Santos, Alexsandro Fernandes, de Oliveira, Cledualdo Soares, de Athayde-Filho, Petrônio Filgueiras |
| Předmět: |
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| Zdroj: |
Molecules; Jan2010, Vol. 15 Issue 1, p128-137, 10p, 1 Diagram, 3 Charts |
| Abstrakt: |
Hydantoins and their derivatives constitute a group of pharmaceutical compounds with anticonvulsant and antiarrhythmic properties, and are also used against diabetes. N-3 and C-5 substituted imidazolidines are examples of such products. As such, we have developed a synthesis of 2,4-dione and 2-thioxo-4-one imidazolidinic derivatives by reaction of amino acids with C-phenylglycine, phenyl isocyanate and phenyl isothiocyanate. Four amino-derivatives IG(1-4) and eight imidazolidinic derivatives, IM(1-8), were obtained in yields of 70-74%. The mass, infrared, ¹H and 13C-NMR spectra of representative products are discussed. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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