| Autor: |
Billoni, Nelly, Buan, Bruno, Gautier, Brigitte, Collin, Christine, Gaillard, Olivier, Mahé, Yann F., Bernard, Bruno A. |
| Předmět: |
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| Zdroj: |
Acta Dermato-Venereologica; Sep/Oct2000, Vol. 80 Issue 5, p329-334, 6p |
| Abstrakt: |
Peroxisome proliferator-activated receptors (PPARs), which belong to the nuclear hormone receptor superfamily, have recently been described as potent key regulators of epidermal development. As 1,25-dihydroxyvitamin D[sub 3], retinoic acid and triiodothyronine are known to exert effects on skin and hair follicle growth through similar receptors, we decided to investigate both the expression pattern of the PPARα, -δ and -γ subtypes and their role in human hair follicles. Using reverse transcriptase-polymerase chain reaction and immunohistochemistry, we established that PPAR α, -δ and -γ were expressed in both dermal and epithelial human hair follicle cells. Additionally, we evaluated the dose effect of clofibrate, a PPARα ligand, on the survival of human hair follicles in culture. A beneficial effect was observed within a narrow range of concentrations. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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