| Autor: |
Frisoni, Giovanni B., Louhija, Jukka, Geroldi, Cristina, Trabucchi, Marco, Frisoni, G B, Louhija, J, Geroldi, C, Trabucchi, M |
| Předmět: |
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| Zdroj: |
Journals of Gerontology Series A: Biological Sciences & Medical Sciences; Feb2001, Vol. 56 Issue 2, pM75-M78, 4p, 2 Charts |
| Abstrakt: |
Background: Whether and which genetic factors affect human longevity is unclear. This study assesses the association between the epsilon2 allele of apolipoprotein E (APOE), a putative longevity gene, and extremely old age.Methods: This study is based on all centenarians living in Finland in 1991. Subjects were 179 persons (28 men and 151 women) aged 100 years and older (response rate, 97%).Results: The percentages of epsilon2-allele carriers in persons aged 100 to 101, 102 to 103, and 104 years and older were 9% (10/117), 21% (9/42), and 25% (5/20; gender-adjusted p for trend = .01), respectively. The effect was particularly strong in women: 8% (8/100), 18% (6/33), and 28% (5/18; p for trend = .01) by age group, respectively. Low cell numbers prevented clear conclusions being drawn for men. Seventeen percent (30/179) of the adult Finnish population were carriers of the epsilon4 allele, a figure lower than expected, and stable by age group.Conclusions: Carriers of the epsilon2 allele of APOE might be predisposed to reach extremely old age. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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