Association of polymorphisms in genes involved in lipoprotein metabolism with plasma concentrations of remnant lipoproteins and HDL subpopulations before and after hormone therapy in postmenopausal women.

Autor: Lamon-Fava, Stefania, Asztalos, Bela F., Howard, Timothy D., Reboussin, David M., Horvath, Katalin V., Schaefer, Ernst J., Herrington, David M.
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Zdroj: Clinical Endocrinology; Feb2010, Vol. 72 Issue 2, p169-175, 7p, 4 Charts
Abstrakt: Objective A high degree of inter-individual variability in plasma lipid level response to hormone therapy (HT) has been reported. Variations in the oestrogen receptor α gene ( ESR1) and in genes involved in lipid metabolism may explain some of the variability in response to HT. Subjects Postmenopausal Caucasian women ( n = 208) participating in a placebo-controlled randomized trial of 3·2 years of hormone therapy (HT). Methods Plasma triglyceride (TG), remnant lipoprotein cholesterol (RLP-C), and high-density lipoprotein cholesterol (HDL-C) levels and HDL subpopulations were assessed at baseline and at follow up. Single nucleotide polymorphisms (SNPs) in ESR1 and in the ATP binding cassette A1 ( ABCA1), cholesteryl ester transfer protein ( CETP), hepatic lipase ( LIPC), lipoprotein lipase ( LPL), and scavenger receptor class B type I ( SRB1) genes were assessed for their association with baseline plasma levels and HT-related changes in levels of RLP-C and HDL subpopulations. Results Carriers of the ESR1 PvuII or IVS1-1505 variants had lower plasma TG concentrations and higher plasma HDL-C and α-1 and preα-1 HDL particle levels at baseline and showed greater increases in HDL-C, apo A-I and α-1 particle levels after HT than wild-type carriers. Carriers of the N291S and D9N variants in the LPL gene had significantly higher remnant lipoproteins and lower α-2 HDL particle levels at baseline. The CETP TaqIB SNP was a significant determinant of baseline plasma HDL-C and HDL subpopulation profile. Conclusions Single nucleotide polymorphisms in ESR1, CETP and LPL had significant effects on baseline plasma levels of TG-rich and HDL subpopulations. With the exception of ESR1 SNPs, variation in genes involved in lipid metabolism has a very modest effect on lipoprotein response to HT. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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