| Autor: |
Hao-Li Liu, Yau-Yau Wai, Po-Hong Hsu, Lee-Ang Lyu, Jia-Shin Wu, Chia-Rui Shen, Jin-Chung Chen, Tzu-Chen Yen, Jiun-Jie Wang |
| Předmět: |
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| Zdroj: |
Journal of Cerebral Blood Flow & Metabolism; Jan2010, Vol. 30 Issue 1, p177-186, 10p, 1 Black and White Photograph, 4 Diagrams, 1 Chart, 2 Graphs |
| Abstrakt: |
Focused ultrasound has been discovered to locally and reversibly increase permeability of the blood–brain barrier (BBB). However, inappropriate sonication of the BBB may cause complications, such as hemorrhage and brain tissue damage. Tissue damage may be controlled by selecting optimal sonication parameters. In this study, we sought to investigate the feasibility of labeling cells with superparamagnetic iron oxide particles to assess the inflammatory response during focused-ultrasound-induced BBB opening. We show that infiltration of phagocytes does not occur using optimal parameters of sonication. Taken together, the results of our study support the usefulness and safety of focused-ultrasound-induced BBB opening for enhancing drug delivery to the brain. These findings may have implications for the optimization of sonication parameters. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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