| Autor: |
Vonasek, Eva, Mateu, Leonardo, Luzzati, Vittorio, Marquez, Gustavo, Vargas, Rodolfo, Céspedes, Ghislaine, Cotúa, Maritza, Borges, Julio |
| Předmět: |
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| Zdroj: |
European Biophysics Journal; 2001, Vol. 30 Issue 1, p11, 6p |
| Abstrakt: |
Abstract A sural nerve dissected from a recently dead patient displayed an unusual X-ray diffraction pattern, suggesting that in situ and at the time of the patient's death the myelin sheaths were in a swollen state. Diffraction patterns of the swollen type were also recorded from: (1) a sural nerve from the corpse of a neurologically healthy person after soaking the nerve with Ringer solution at pH 5.5; (2) sciatic nerves dissected from rat cadavers at increasing time after death. In all the cases the swollen patterns reversed to the native type upon superfusion with Ringer solution at pH 7.3. The postmortem effect is to decrease the pH of the fluids surrounding the nerves in the cadavers. Our experiments show that the early postmortem processes have the effect of acidifying PNS nerves and that as a consequence of acidification the myelin sheaths swell. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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