| Autor: |
Domschke, Christoph, Schuetz, Florian, Sommerfeldt, Nora, Rom, Joachim, Scharf, Alexander, Sohn, Christof, Schneeweiss, Andreas, Beckhove, Philipp |
| Předmět: |
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| Zdroj: |
Cancer Immunology, Immunotherapy; Mar2010, Vol. 59 Issue 3, p479-486, 8p, 2 Graphs |
| Abstrakt: |
Tumor-specific memory T cells are detectable in the bone marrow (BM) of a majority of breast cancer patients. In vitro they can be reactivated to IFN-γ producing, cytotoxic effector cells and reject autologous, xenotransplanted tumors in NOD/SCID mice after specific restimulation with autologous dendritic cells (DC). In this study, we demonstrate the presence of specific tumor-reactive BM memory T cells in altogether 56 out of 129 primarily operated breast cancer patients by short-term IFN-γ EliSpot assays with unstimulated T cells and tumor antigen presenting, autologous DCs. We observed tumor-reactive BM memory T cells predominantly in patients with primarily metastatic disease ( P = 0.011) or with increased concentrations of tumor marker CA 15-3 in the peripheral blood ( P = 0.004), respectively. Memory T cell reactivity against HLA-A*0201-restricted peptides from the tumor-associated antigens MUC1, Hpa16–24 and Hpa183–191 was also detected particularly in patients with elevated peripheral CA 15-3 concentrations ( P < 0.05). Altogether these data indicate that the systemic presence of tumor-derived antigens promotes an induction of tumor-specific cellular immune responses in the human BM. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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