Genetic and pharmacological disruption of neurokinin 1 receptor function decreases anxiety...

Autor: Santarelli, Luca, Gobbi, Gabriella, Debs, Pierre C., Sibille, Etienne L., Blier, Pierre, Hen, Rene, Heath, Mark J.S.
Předmět:
Zdroj: Proceedings of the National Academy of Sciences of the United States of America; 02/13/2001, Vol. 98 Issue 4, p1912, 6p, 4 Color Photographs, 8 Black and White Photographs, 11 Graphs
Abstrakt: Evaluates the function of serotonergic neurons in the dorsal raphe nucleus in animals to determine whether the anxiolytic effect of neurokinin 1 receptor (NK1R) disruption was independent of monoamine transmitter systems. Role of Substance P in the generation of anxiety-related behaviors in mice; Effects of NK1R antagonism on 5-HT function.
Databáze: Complementary Index