| Autor: |
Broocks, Andreas, Meyer, Tim, Gleiter, C.H., Hillmer-Vogel, Ursula, George, Annette, Bartmann, Uwe, Bandelow, Borwin |
| Předmět: |
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| Zdroj: |
Psychopharmacology; 2001, Vol. 155 Issue 3, p234, 8p, 3 Charts, 2 Graphs |
| Abstrakt: |
Abstract Rationale: Several clinical studies suggest antidepressive and anxiolytic effects of regular aerobic exercise. Objectives: The present study examines the effects of a 10-week protocol of moderate aerobic exercise (3-4 miles jogging 3 times per week) on central serotonergic receptor sensitivity. Methods: Neuroendocrine challenges using oral doses of meta-chlorophenylpiperazine (m-CPP; 0.4 mg/kg), ipsapirone (0.3 mg/kg), and placebo were performed in 12 untrained healthy volunteers before and after 10 weeks of moderate aerobic exercise. Results: Before training, administration of the non-selective serotonergic agonist m-CPP, which exerts a number of well-reproducible effects mainly via its action on 5-HT[sub 2C] receptors, was associated with a significant increase of cortisol and prolactin (but not adrenaline or noradrenaline) in comparison with the placebo condition. After the 10-week training period, administration of m-CPP was followed by a blunted cortisol response which was not significantly increased in comparison to the placebo challenge. In contrast, the increases of cortisol observed after administration of the 5-HT[sub 1A] agonist ipsapirone were of the same magnitude during the pre- and post-training challenge sessions. The behavioral response to ipsapirone and the mean maximal increases of plasma adrenaline and noradrenaline did not change during the training period. Conclusions: Regular aerobic exercise is associated with a blunted cortisol response to m-CPP, which might reflect a downregulation of central 5-HT[sub 2C] receptors. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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