| Autor: |
Fu-Shun Yu, Chih-Chung Wu, Chi-Tsai Chen, Shang-Pang Huang, Jai-Sing Yang, Yuan-Man Hsu, Ping-Ping Wu, Siu-Wan Ip, Jing-Pin Lin, Jaung-Geng Lin, Jing-Gung Chung |
| Předmět: |
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| Zdroj: |
Human & Experimental Toxicology; Dec2009, Vol. 28 Issue 12, p785-790, 6p, 1 Color Photograph, 1 Black and White Photograph, 3 Graphs |
| Abstrakt: |
It is well documented that enhanced garlic (Allium sativum) consumption leads to decrease in the cancer incidences. Diallyl sulfide (DAS), one of the components of garlic, induces cytotoxicity and apoptosis in many cancer cell lines. The present studies are focused on the in vivo effects of DAS on leukemia WEHI-3 cells in the BALB/c mice. We examined the effects of DAS on the cytotoxicity of WEHI-3 cells and results indicated that DAS decreased the percentage of viableWEHI-3 cells and these effects are dose-dependent.We examined the effects of DAS on WEHI-3 in vivo and the results indicated that DAS decreased the percentage of Mac-3 and CD11b, indicating that the differentiation of the precursor ofmacrophage cells was inhibited. DAS stimulated the percentage of CD3 and CD19, indicating that the differentiation of the precursor of T and B cells promoted. The weights of liver and spleen indicated that DAS decreased the weight of these organs after being compared to the control groups.One of the major characteristic ofWEHI-3 leukemia is the enlarged spleen in murine after intraperitoneal (i.p.) injection of WEHI-3 cells. In conclusion, DAS affects WEHI-3 cells both in vitro and in vivo. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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