| Autor: |
Zuliani, G., Ble', A., Zanca, R., Munari, M. R., Zurlo, A., Vavalle, C., Atti, A. R., Fellin, R. |
| Předmět: |
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| Zdroj: |
Acta Neurologica Scandinavica; May2001, Vol. 103 Issue 5, p304-308, 5p |
| Abstrakt: |
Objectives – Paraoxonase, angiotensin-converting enzyme (ACE), methylenetetrahydrofolate reductase (MTHFR), and apo E gene polymorphisms were evaluated in older patients with vascular dementia (VD) or late-onset Alzheimer's disease (LOAD). Material and methods – Sixty patients with VD, 45 patients with LOAD, and 54 non-demented controls were compared. Results – No differences in the distribution of paraoxonase, ACE, and MTHFR polymorphisms were found. The overall frequency of apo E ε4 allele was “low”; ε4 allele was more frequent in LOAD (17.5%) and VD (13.3%) compared with controls (9.2%), but the difference was not statistically significant. Conclusion – Paraoxonase, ACE, and MTHFR polymorphisms were not associated with VD or LOAD; these common polymorphisms might have a marginal role in the pathogenesis of dementia in older subjects. In spite of a “low” frequency of the apo E ε4 allele in our sample, the frequency of ε4 allele was about double in LOAD compared with controls. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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