Effect of Transplantation of Peripheral Blood Mononuclears Obtained Using Granulocytic Colony-Stimulating Factor and Hyaluronidase on Regeneration of Hemopoietic Tissue during Myelosuppression.

Autor:	A. Dygai, G. Zyuz’kov, V. Zhdanov, E. Simanina, L. Stavrova, E. Udut, T. Khrichkova, M. Minakova, N. Ermakova, T. Firsova
Předmět:	CELL transplantation BLOOD cells GRANULOCYTES COLONY-stimulating factors (Physiology) HEMATOPOIETIC system ENZYMES REGENERATION (Biology) FIBROBLASTS
Zdroj:	Bulletin of Experimental Biology & Medicine; Jul2009, Vol. 148 Issue 1, p120-125, 6p
Abstrakt:	The mechanisms of hemopoiesis recovery after transplantation of peripheral blood mononuclears obtained using granulocytic CSF and granulocytic CSF in combination with hyaluronidase were studied on the model of cytostatic myelosuppression. It was found that regeneration of the hemopoietic tissue resulted from an increase in the pool of erythroid and granulomonocytic precursors and in their functional activity. The increase in the count of fibroblast precursors in the bone marrow, higher production of hemopoietins by adherent myelokaryocytes, and an increase in the level of humoral factors in the serum were detected after injection of the transplants. A higher therapeutic efficiency of cell material obtained after combined use of granulocytic CSF and hyaluronidase was shown. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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