Spontaneous recovery of myocardial function after ligation of Ameroid-stenosed coronary artery.

Autor: Pätilä, Tommi, Ikonen, Tuija, Kankuri, Esko, Ahonen, Aapo, Krogerus, Leena, Lauerma, Kirsi, Harjula, Ari
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Zdroj: Scandinavian Cardiovascular Journal; Dec2009, Vol. 43 Issue 6, p408-416, 9p, 1 Black and White Photograph, 1 Diagram, 5 Graphs
Abstrakt: Objectives. We aimed to assess the spontaneous healing of myocardial function after occlusion of a chronically stenosed coronary vessel in a porcine model. Design. Ischemia and infarction was produced by Ameroid constrictor placement and a subsequent ligation of the left circumflex artery. Cardiac MRI and 18FDG-PET were performed one and five weeks later. Ki67 staining was used to identify proliferating cells. Results. Restoration of perfusion defect was detected by MRI (p=0.0065), reduced systolic function of the lateral segment spontaneously recovered (p=0.03). There was also a suggestive raise in impaired ejection fraction (p=0.06). Left ventricular early diastolic filling and peak filling rate were substantially improved (p=0.039 and p=0.0078). Scar size reduced (p=0.03). On the 18FDG-PET, deranged metabolism was alleviated (p=0.03). Cardiomyocytes with positive Ki-67 staining were located principally in the non-infarcted myocardium as compared to the infarction or border areas (p=0.037). Conclusions. We demonstrated spontaneous functional healing of ischemic and infarcted left ventricle, suggesting border zone perfusion recovery. Scar reduction was detected. Different pattern of myocyte proliferation between infarction and non-ischemic myocardium was seen. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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