| Autor: |
Ahnen, Dennis J., Byers, Tim |
| Předmět: |
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| Zdroj: |
American Journal of Gastroenterology (Springer Nature); Dec2009, Vol. 104 Issue 12, p3024-3026, 3p |
| Abstrakt: |
Statins are among the most widely prescribed drugs in the United States. In addition to their established lipid-lowering and cardiovascular protective effect, some case–control studies have suggested that statins could have chemopreventive effects for colorectal cancer (CRC). In this issue of the Journal, Singh et al. examined this question using a potentially powerful population-based “electronic cohort” design, which essentially eliminates many of the biases inherent in case–control and traditional cohort studies. They found no evidence of a chemoprotective effect of statin use, a finding that is consistent with previous cohort and interventional studies that have addressed this issue. We conclude that the best-designed studies of the issue indicate that statin use is neither a major risk factor nor a protective factor for CRC and that we have come very near to the end of the road for the hypothesis relating statins to CRC risk. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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