| Autor: |
Roche, N., Lackmy, A., Achache, V., Bussel, B., Katz, R. |
| Zdroj: |
Journal of Physiology; Dec2009, Vol. 587 Issue 23, p5653-5664, 12p, 1 Diagram, 5 Graphs |
| Abstrakt: |
Transcranial direct current stimulation (tDCS) when applied over the motor cortex, modulates excitability dependent on the current polarity. The impact of this cortical modulation on spinal cord network excitability has rarely been studied. In this series of experiments, performed in healthy subjects, we show that anodal tDCS increases disynaptic inhibition directed from extensor carpi radialis (ECR) to flexor carpi radialis (FCR) with no modification of presynaptic inhibition of FCR Ia terminals and FCR H-reflex recruitment curves. We also show that cathodal tDCS does not modify spinal network excitability. Our results suggest that the increase of disynaptic inhibition observed during anodal tDCS relies on an increase of disynaptic interneuron excitability and that tDCS over the motor cortex in human subjects induces effects on spinal network excitability. Our results highlight the fact that the effects of tDCS should be considered in regard to spinal motor circuits and not only to cortical circuits. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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