| Autor: |
Koryakin, S. N., Yadrovskaya, V. A., Baranov, A. P., Isaeva, E. V., Ul'yanenko, S. E. |
| Předmět: |
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| Zdroj: |
Pharmaceutical Chemistry Journal; Aug2009, Vol. 43 Issue 8, p436-438, 3p, 1 Chart, 2 Graphs |
| Abstrakt: |
The biodistribution of sodium mercaptododecaborate labeled with radioactive iodine (131I-BSH) in melanoma B-16 and surrounding tissues in mice has been studied for administration by various methods including intraperitoneal, single and double intratumor injection, and introduction under tumor bed. It is shown that a high content of 131I-BSH in the tumor is reached in all cases. The maximum accumulation of the boron compound is observed 1 h after administration. In this case the ratio of radioactivities in melanoma B-16 and surrounding tissues in most animals was greater than 3. A study of 131I-BSH uptake in tumor cells showed that a considerably greater accumulation of the compound is observed 3 and 6 h after intraperitoneal administration in the intercellular space (65.3% and 63.0%, respectively) in comparison to the cellular content (34.7% and 37.0%, respectively). The levels of accumulation become identical in about 12 h after administration. Approximately equal uptake of the boron compound in the intercellular space and tumor cells was observed over the entire period of investigation (0.5–2 h) after a single intratumor administration of 131I-BSH. The results of this study suggest that the intratumor administration of boron compounds is promising for neutron capture therapy, especially in combination with neutron teletherapy. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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