Heart rate variability and n-3 polyunsaturated fatty acids in patients with diabetes mellitus.

Autor:	Christensen, J. Hagtrup, Skou, H. Aarup, Madsen, T., Tørring, I., Schmidt, E. Berg, Christensen, J H, Skou, H A, Tørring, I, Schmidt, E B
Předmět:	HEART beat UNSATURATED fatty acids DIET therapy for diabetes AMBULATORY electrocardiography ANIMAL experimentation CHI-squared test COMPARATIVE studies DIABETES FISHES RESEARCH methodology MEDICAL cooperation NONPARAMETRIC statistics OMEGA-3 fatty acids RESEARCH EVALUATION research
Zdroj:	Journal of Internal Medicine; Jun2001, Vol. 249 Issue 6, p545-552, 8p, 5 Charts
Abstrakt:	Objectives: Dietary n-3 polyunsaturated fatty acids (PUFA) derived from fish may reduce the incidence of sudden cardiac death (SCD). The aim of the present study was to examine associations between n-3 PUFA and 24-h heart rate variability in patients with type 1 and type 2 diabetes mellitus (DM).Design: Observational study.Setting: The out-patient's diabetic clinic at Hjørring Hospital, Hjørring, Denmark.Subjects: Forty-three patients with type 1 DM and 38 patients with type 2 DM.Main Outcome Measures: The patients fulfilled a food-questionnaire regarding fish consumption, whilst the content of n-3 PUFA in platelets was measured and 24-h heart rate variability (HRV) was obtained.Results: The patients fish consumption was strongly related to their content of n-3 PUFA in platelets. Furthermore, in patients with type 1 DM a close positive association was found between the content of n-3 PUFA in platelets and 24-h HRV. This association was not significant in patients with type 2 DM.Conclusions: The positive association between n-3 PUFA in platelets and HRV may indicate a beneficial effect of n-3 PUFA on HRV in patients with type 1 DM. Further studies are warranted to clarify whether supplementation with n-3 PUFA reduce the risk of SCD amongst patients with DM. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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