| Autor: |
Oramas-Shirey, Martha P., Buchanan, Lewis V., Dileto-Fang, Christine L., Dailey, Charlene F., Ford, Charles W., Batts, Donald H., Gibson, John K., Oramas-Shirey, M P, Buchanan, L V, Dileto-Fang, C L, Dailey, C F, Ford, C W, Batts, D H, Gibson, J K |
| Zdroj: |
Journal of Antimicrobial Chemotherapy (JAC); Mar2001, Vol. 47 Issue 3, p349-352, 4p |
| Abstrakt: |
A rabbit endocarditis model was used to test the efficacy of oral linezolid and iv vancomycin. Twenty-four hours after catheter placement across the aortic valve, rabbits were infected with 3.5 x 10(6) cfu of Staphylococcus aureus (UC-9258). Two days after infection, control rabbits were killed, and treated rabbits were given 5 days of therapy with linezolid at 8 h intervals (tds) using either 25, 50 or 75 mg/kg/dose, or vancomycin at 12 h intervals (bd) using 25 mg/kg/dose. Linezolid at 75 and 50 mg/kg, and vancomycin significantly reduced S. aureus in aortic valve vegetations compared with the control. Linezolid at 25 mg/kg was ineffective. The efficacy of 75 and 50 mg/kg linezolid was related to maintenance of plasma drug levels near or above the linezolid MIC for UC-9258 (2 mg/L). [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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