Activity of buforin II alone and in combination with azithromycin and minocycline against Cryptosporidium parvum in cell culture.

Autor: Giacometti, Andrea, Cirioni, Oscar, Del Prete, Maria Simona, Barchiesi, Francesco, Fineo, Anna, Scalise, Giorgio, Giacometti, A, Cirioni, O, Del Prete MS, Barchiesi, F, Fineo, A, Scalise, G
Zdroj: Journal of Antimicrobial Chemotherapy (JAC); Jan2001, Vol. 47 Issue 1, p97-99, 3p
Abstrakt: The in vitro anti-cryptosporidial activity of buforin II alone and in combination with azithromycin and minocycline was investigated. Buforin II showed moderate activity, which increased with increasing concentration to 55.7% suppression of growth at 20 microM. Moreover, its activity was enhanced when it was combined with either azithromycin or minocycline with >90% parasite reduction at the highest concentration tested. Buforin II may be active in inhibiting Cryptosporidium parvum growth in vitro upon combination with either azithromycin or minocycline. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index