Eradication of non-typhoid salmonellae in acute enteritis after therapy with ofloxacin for 5 or 10 days.

Autor: Voltersvik, Pål, Halstensen, Alfred, Langeland, Nina, Digranes, Asbjørn, Peterson, Lars Erik, Rolstad, Tore, Solberg, Claus Ola, Voltersvik, P, Halstensen, A, Langeland, N, Digranes, A, Peterson, L E, Rolstad, T, Solberg, C O
Zdroj: Journal of Antimicrobial Chemotherapy (JAC); Sep2000, Vol. 46 Issue 3, p457-459, 3p
Abstrakt: Eradication of non-typhoid salmonellae was evaluated in a randomized, double-blinded study of 49 patients with acute enteritis after therapy with ofloxacin 400 mg once daily for 5 or 10 days. Early eradication of salmonellae was found in 57% of patients in the 5 day therapy group and in 74% of patients in the 10 day therapy group. This difference was larger among severely ill patients. Together with our previous study of ofloxacin therapy for 3 days or placebo, this shows that early eradication of non-typhoid salmonellae increases with duration of ofloxacin therapy without an increase in persistence of salmonellae in stools or development of resistant strains. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index