The 185delAG BRCA1 mutation originated before the dispersion of Jews in the Diaspora and is not limited to Ashkenazim.

Autor: Bar‐Sade, Revital Bruchim, Kruglikova, Anna, Modan, Baruch, Gak, Eva, Hirsh‐Yechezkel, Galit, Theodor, Livia, Novikov, Ilya, Gershoni‐Baruch, Ruth, Risel, Shulamit, Papa, Moshe Z., Ben‐Baruch, Gilad, Friedman, Eitan
Zdroj: Human Molecular Genetics; May98, Vol. 7 Issue 5, p801, 5p
Abstrakt: Presents evidence supporting the hypothesis that the 185delAG germline mutation in BRCA1 originated before the dispersion of Jews in the Diaspora and is not limited to Ashkenazim. Overview of the search for germline mutations within breast and ovarian cancer susceptibility genes; Characteristics of non-Ashkenazi mutation carriers from the Oncogenetics service.
Databáze: Complementary Index