| Abstrakt: |
Thirty seven taxanes were characterized from the leaves and twigs of Taiwanese yew Taxus sumatrana, Taxaceae. Four of these metabolites are new and designated as sumataxins A–D 1–4. Compound 1possesses an 1115→1,1110→9diabeotaxane skeleton with an unusual spiroconnected 2,2dimethyl1,3dioxolane ring at C4, whereas compound 2has a rare βOH orientation at C13 of taxane diterpene ester. In addition, sumataxin C 3 is formulated as an 1115→1abeotaxane with a 4,5acetonide ring skeleton. Compound 4is the first metabolite with a 4,20epoxytaxane structure. The structures of all the taxanes were established by spectroscopic methods. All compounds were evaluated for antiHSV1 and PBMC activities. Compound 9exhibited significant enhancement of cell proliferation on peripheral blood mononuclear cells. [ABSTRACT FROM AUTHOR] |
Plný text