Lipid-Soluble Extracts as the Main Source of Anticancer Activity in Ginseng and Ginseng Marc.

Autor: Sung Dong Lee, Guijae Yoo, Hee Jeong Chae, Man-Jin In, Nam-Soon Oh, Yoon Kyung Hwang, Woo Ik Hwang, Dong Chung Kim
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Zdroj: Journal of the American Oil Chemists' Society (JAOCS); Nov2009, Vol. 86 Issue 11, p1065-1071, 7p, 1 Diagram, 1 Chart, 3 Graphs
Abstrakt: The anticancer activity of ginseng originated mainly from lipid-soluble components. The hexane extract of ginseng marc (HEGM) showed a potent inhibitory activity on human hepatoma (HepG2, GI50 = 41.7 μg/ml) and breast (MCF-7, GI50 = 54.4 μg/ml) cancer cell proliferation in vitro in a concentration-dependent manner as did the hexane extract of ginseng (HEG), with GI50 values of 21.1 μg/ml in HepG2 and 41.2 μg/ml in MCF-7. The water extract of ginseng (WEG) possessed a low anticancer activity against both cancer cell lines, but the hexane-soluble fraction of WEG (HSF/WEG) showed a potent anticancer activity against HepG2 (GI50 = 38.7 μg/ml) and MCF-7 cells (GI50 = 51.1 μg/ml). The hexane extraction in ginseng was a very promising protocol for the maximum recovery of the anticancer active components in high concentrations. Also the adoption of hexane extraction after water extraction of ginseng was successful in the effective utilization of the residual lipid-soluble anticancer active components in ginseng marc. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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