| Autor: |
Hart, R. W., Dixit, R., Seng, J., Turturo, A., Leakey, J. E. A., Feuers, R., Duffy, P., Buffington, C., Cowan, G., Lewis, S., Pipkin, J., Li, S. Y. |
| Předmět: |
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| Zdroj: |
Toxicological Sciences; Dec1999, Vol. 52 Issue 2, p3-12, 10p |
| Abstrakt: |
Carcinogenicity and aging are characterized by a set of complex endpoints, which appear as a series of molecular events. Many of these events can be modified by caloric intake. Since most of these processes determine an organism's ability to cope with various environmental stressors, it is not surprising that a relationship (in the presence of a constant nutrient density) exists between caloric intake and time-to-tumor and/or life span. Our studies have clearly shown that generally, the greater the caloric intake, the greater the body weight, the higher the incidence of spontaneous tumor occurrence, the greater the susceptibility to chemical carcinogens, and the shorter the life span. It is also recognized that variables other than body weight influence the life span and carcinogenesis. We have focused our attention on the questions of how and to what extent caloric intake modifies those homeostatic processes believed to be critical in determining the ability of an organism to cope with endogenous and exogenous stresses such as chemical, physical, and biological carcinogens. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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