| Autor: |
Seaton, R. A., Steinke, D. T., Phillips, G., MacDonald, T., Davey, P. G. |
| Zdroj: |
Journal of Antimicrobial Chemotherapy (JAC); Aug2000, Vol. 46 Issue 2, p307-309, 3p |
| Abstrakt: |
The study objective was to determine whether recent community antibiotic prescribing and hospitalization are associated with β-lactam resistance in respiratory isolates of Haemophilus influenzae. Data obtained for hospitalization and community prescribing (in the previous 3 months) from 412 adults (>15 years) in whom an episode of respiratory tract infection had been described, during which H. influenzae was isolated, were analysed. Seventy-three (17.7%) isolates of H. influenzae were resistant to amoxycillin. Resistance was associated with recent hospitalization [odds ratio (OR) 3.2, 1.8–5.6] and antibiotic exposure in the community (2.1, 1.2–3.6). These variables were independently associated with amoxycillin resistance [hospitalization (OR 4.5, 1.7–12.5) and community β-lactam antibiotic exposure (3.9, 1.6–9.8)]. Hospitalized patients probably received antibiotics during their admission although aquisition of the organism or the β-lactamase via plasmids from other Gram-negative organisms in the hospital could also be a factor. Control measures to reduce the inappropriate use of antimicrobials in the community and in hospital need to be reinforced. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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