| Autor: |
Messick, Chad R., Rodvold, Keith A., Pendland, Susan L., Messick, C R, Rodvold, K A, Pendland, S L |
| Zdroj: |
Journal of Antimicrobial Chemotherapy (JAC); Dec1999, Vol. 44 Issue 6, p831-834, 4p |
| Abstrakt: |
This study used a modified time–kill assay to compare the in-vitro activity of chloramphenicol and quinopristin/dalfopristin combined with vancomycin, ampicillin or gentamicin against multidrug-resistant Enterococcus faecium. The assay uses standardized time–kill methods with the following modifications: centrifugation of the test tubes at 1–2 h intervals, removal of supernatant and resuspension of bacteria in media containing antibiotic concentrations corresponding to simulated steady-state serum concentrations. None of the agents, alone or in combination, produced bactericidal or synergic activity. The modified time–kill assay more closely simulates in-vivo conditions and may provide a better qualitative assay to determine the interaction between antimicrobial agents and bacteria. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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