Neuropsychiatric systemic lupus erythematosus and the syndrome of inappropriate secretion of antidiuretic hormone: a case report with very late onset systemic lupus erythematosus.

Autor: Mirsattari, SM, Power, C, Fine, A, McGinn, GS, Ludwick, S, Canvins, JMG
Zdroj: British Journal of Rheumatology; Oct1998, Vol. 37 Issue 10, p1132-1134, 3p
Abstrakt: The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) associated with neuropsychiatric lupus (NP-SLE) is rare. We report a case of SIADH associated with the new onset of SLE in an 88-yr-old female. The unique features of this case include the extreme age of onset of SLE presenting with neuropsychiatric manifestations and positive antiribosomal P antibody titres. Both the NP manifestations of SLE and SIADH were highly correlated with the SLE disease activity. This case illustrates a novel presentation of NP-SLE with SIADH which may develop due to antibody-mediated hypothalamic dysfunction. [ABSTRACT FROM PUBLISHER]
Databáze: Complementary Index