| Autor: |
Kronin, V, Vremec, D, Shortman, K |
| Zdroj: |
International Immunology; Feb1998, Vol. 10 Issue 2, p237-240, 4p |
| Abstrakt: |
The IL-2 receptor (IL-2R) α chain (CD25), but not the IL-2R β chain, is induced on dendritic cells (DC) by brief periods of culture. To test if this IL-2Rα is important for DC function, DC were isolated from the spleens of mutant mice with the IL-2Rα gene disrupted and compared with normal DC for ability to stimulate proliferation of allogeneic CD4 and CD8 T cells in culture. The IL-2Rα null DC and the normal DC produced nearly identical proliferative responses from CD4 and from CD8 T cells. When the CD8α+ and CD9α- subsets of the IL-2Rα null DC were separated, they also produced proliferative responses similar to that of their normal DC counterparts. Overall there was no evidence that the inducible IL-2Rα on DC was required for DC development, for stimulation of T cells or for regulation of T cell responses. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
