Renal osteopontin protein and mRNA upregulation during acute nephrotoxicity in the rat.

Autor: Verstrepen, Walter A., Persy, Veerle P., Verhulst, Anja, Dauwe, Simonne, De Broe, Marc E.
Zdroj: Nephrology Dialysis Transplantation; Apr2001, Vol. 16 Issue 4, p712-724, 13p
Abstrakt: Background. The effect of segment‐specific proximal tubular injury on spatio‐temporal osteopontin (OPN) distribution was determined in two different nephrotoxic rat models to evaluate its conceivability with a possible role for OPN in acute renal failure (ARF). OPN gene expression was further determined in proximal and distal tubular cells to investigate the origin of increased renal OPN. [ABSTRACT FROM PUBLISHER]
Databáze: Complementary Index