| Autor: |
Freedman, Barry I., Yu, Hongrun, Anderson, Pamela J., Roh, Bong H., Rich, Stephen S., Bowden, Donald W. |
| Zdroj: |
Nephrology Dialysis Transplantation; Nov2000, Vol. 15 Issue 11, p1794-1800, 7p |
| Abstrakt: |
Background. Genetic factors have been implicated in the development of the common aetiologies of end‐stage renal disease (ESRD), including renal failure attributed to hypertension, diabetes mellitus, systemic lupus erythematosus and human immunodeficiency virus infection. Nitric oxide (NO) and endothelin are powerful vasoactive mediators involved in inflammation and regulation of vascular tone and blood pressure. We evaluated the role of the neuronal constitutive (NOS1) and endothelial constitutive (NOS3) nitric oxide synthase genes and the endothelin‐1 (EDN‐1) gene in predisposition to chronic renal failure in African–Americans. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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