Effect of mycophenolate mofetil on erythropoiesis in stable renal transplant patients is correlated with mycophenolic acid trough levels.

Autor: van Besouw, Nicole M., van der Mast, Barbara J., Smak Gregoor, Peter J. H., Hesse, Cees J., IJzermans, Jan N. M., van Gelder, Teun, Weimar, Willem
Zdroj: Nephrology Dialysis Transplantation; Nov1999, Vol. 14 Issue 11, p2710-2713, 4p
Abstrakt: Background. Both mycophenolate mofetil (MMF) and azathioprine (AZA) are immunosuppressive drugs that inhibit purine synthesis. In theory, MMF selectively inhibits lymphocyte proliferation, while AZA has well-known effects on red blood cells and thrombocytes as well. In renal transplant recipients we replaced CsA therapy by MMF in an attempt to reduce the immunosuppressive load 1 year after kidney transplantation. During this study we observed the effect of MMF on haematological parameters such as haemoglobin (Hb), leukocytes, and thrombocytes. [ABSTRACT FROM PUBLISHER]
Databáze: Complementary Index