| Autor: |
Vraetz, Thomas, Ittel, Thomas H., van Mackelenbergh, Michelle G., Heinrich, Peter C., Sieberth, H. G., Graeve, Lutz |
| Zdroj: |
Nephrology Dialysis Transplantation; Sep1999, Vol. 14 Issue 9, p2137-2143, 7p |
| Abstrakt: |
Background. Proinflammatory monocytic cytokines such as interleukin-1 (IL-1), tumour necrosis factor-α (TNF-α) and IL-6 have been incriminated in the pathogenesis of elevated β2-microglobulin (β2M) serum concentrations in patients undergoing haemodialysis with so-called bioincompatible dialyser membranes. However, neither the source of the elevated serum β2M nor the precise role of monocytic cytokines in the expression of the β2M gene have been elucidated conclusively. The aim of the current study was to evaluate whether monoytic cytokines, and in particular IL-6, are regulators of β2M gene expression in human hepatoma cells, T-lymphocytes and monocytes. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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