| Autor: |
Nagashima, Satoru, Kozawa, Osamu, Otsuka, Takanobu, Kohno, Ken-ichi, Minamoto, Masahiko, Yokokawa, Masahiro, Kanamaru, Mitsutaka, Uematsu, Toshihiko, Nagashima, S, Kozawa, O, Otsuka, T, Kohno, K, Minamoto, M, Yokokawa, M, Kanamaru, M, Uematsu, T |
| Předmět: |
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| Zdroj: |
Journal of Antimicrobial Chemotherapy (JAC); Nov2000, Vol. 46 Issue 5, p839-842, 4p |
| Abstrakt: |
The effects of haemodialysis on the pharmacokinetics of a carbapenem, biapenem, were evaluated in five patients with end-stage renal disease, who received 1 h iv infusions of 300 mg biapenem on both the days on and off 4 h haemodialysis. With haemodialysis, plasma biapenem exhibited two elimination phases, one during and the other after haemodialysis with half-lives of 1.16 ± 0.12 and 3.33 ± 0.91 h, respectively. Ninety percent of biapenem was removed from blood to dialysate. Without haemodialysis, plasma biapenem was mono-exponentially eliminated with a half-life of 4.35 ± 1.30 h. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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