| Autor: |
Molina, Judith, Brener, Zigman, Romanha, Alvaro J., Urbina, Julio A. |
| Zdroj: |
Journal of Antimicrobial Chemotherapy (JAC); Jul2000 Supplement 1, Vol. 46, p137-140, 4p |
| Abstrakt: |
We report the in vivo activity of the bis-triazole derivative D0870 against a variety of strains of Trypanosoma cruzi, the causative agent of Chagas' disease, including nitroimidazole/nitrofuran-resistant strains. In both acute and chronic murine models of the disease, treatment with D0870 at ≤ 10 mg/kg on alternate days for a total of 20 doses provided 60–100% protection against death, regardless of the drug sensitivity of the infecting strain. In the acute model we obtained 70–100% parasitological cure in seven of the nine strains tested, including one intermediate and two highly drug-resistant strains. D0870 was able to cure 30–45% of animals chronically infected with various strains, including those harbouring the Colombiana strain, among which no cures were obtained with benznidazole. We also found that the anti-T. cruzi activity of D0870 is largely retained even if the hosts are immunosuppressed. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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