| Autor: |
Darley, Elizabeth S. R., Bowker, Karen E., Lovering, Andrew M., Harvey, John E., Macgowan, Alasdair P., Darley, E S, Bowker, K E, Lovering, A M, Harvey, J E, Macgowan, A P |
| Zdroj: |
Journal of Antimicrobial Chemotherapy (JAC); Feb2000, Vol. 45 Issue 2, p247-250, 4p |
| Abstrakt: |
Meropenem administered as a single iv 3 g dose once every 24 h was used to treat nine ambulatory patients with infective exacerbations of bronchiectasis. Serum meropenem concentrations were measured before dosing and at 30 min after each 30 min infusion. Mean pre-dose concentrations were <0.1 mg/L and mean post-dose concentrations 93.9 ± 29.5 mg/L (95% confidence interval (CI) 86.2–101.6, n = 59). A pathogen was cultured from sputum in six patients and eradicated (<100 cfu/g sputum) in all but one by day 6 of therapy. Previous work on animals has shown that a bacteriostatic effect is seen with meropenem when t > MIC is greater than 20–30% of the dose interval. In these nine patients, this could be achieved and was associated with successful outcome for pathogens for which MICs are ≤ 0.5 mg/L. Therefore, once-a-day meropenem therapy may be a useful option for outpatient treatment for isolates for which MICs are ≤ 0.5 mg/L. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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