| Autor: |
Nikolova, Kalina A., Tchorbanov, Andrey I., Djoumerska-Alexieva, Iglika K., Nikolova, Maria, Vassilev, Tchavdar L. |
| Předmět: |
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| Zdroj: |
Immunology & Cell Biology; Oct2009, Vol. 87 Issue 7, p529-533, 5p, 3 Graphs |
| Abstrakt: |
Intravenous immunoglobulin (IVIg) preparations are known to modulate autoimmune/inflammatory diseases through several F(ab')2- and Fc-dependent mechanisms. In this study, we show that the in vitro and the in vivo exposure of B lymphocytes from lupus-prone and from healthy mice to IVIg results in an increased expression of their surface inhibitory FcγIIB receptors. Further, this exposure enhanced the ability of a chimeric antibody, cross-linking FcγRIIB and immunoglobulin receptors on DNA-specific B lymphocytes, to suppress IgG anti-DNA antibody production. F(ab')2 fragments of IVIg had a similar activity as the intact preparation, whereas Fc fragments had no effect. This study describes a novel approach with clinical relevance for modulating B lymphocyte activity. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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