| Autor: |
Porta, Francesca, Bracht, Hendrik, Weikert, Christian, Beck, Mario, Takala, Jukka, Brandt, Sebastian, Hiltebrand, Luzius B., Jakob, Stephan M. |
| Předmět: |
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| Zdroj: |
Inflammation; Oct2009, Vol. 32 Issue 5, p315-321, 7p, 4 Charts, 2 Graphs |
| Abstrakt: |
Catecholamines are frequently used in sepsis, but their interaction with mitochondrial function is controversial. We incubated isolated native and endotoxin-exposed swine liver mitochondria with either dopamine, dobutamine, noradrenaline or placebo for 1 h. Mitochondrial State 3 and 4 respiration and their ratio (RCR) were determined for respiratory chain complexes I, II and IV. All catecholamines impaired glutamate-dependent RCR ( p = 0.046), predominantly in native mitochondria. Endotoxin incubation alone induced a decrease in glutamate-dependent RCR compared to control samples ( p = 0.002). We conclude that catecholamines and endotoxin impair the efficiency of mitochondrial complex I respiration in vitro. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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