| Autor: |
Kaderali, Lars, Dazert, Eva, Zeuge, Ulf, Frese, Michael, Bartenschlager, Ralf |
| Předmět: |
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| Zdroj: |
Bioinformatics; Sep2009, Vol. 25 Issue 17, p2229-2235, 7p, 2 Diagrams, 2 Graphs |
| Abstrakt: |
Motivation: The reconstruction of signaling pathways from gene knockdown data is a novel research field enabled by developments in RNAi screening technology. However, while RNA interference is a powerful technique to identify genes related to a phenotype of interest, their placement in the corresponding pathways remains a challenging problem. Difficulties are aggravated if not all pathway components can be observed after each knockdown, but readouts are only available for a small subset. We are then facing the problem of reconstructing a network from incomplete data. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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