Short-term exercise training improves aerobic capacity with no change in arterial function in obesity.

Autor:	Baynard, Tracy, Carhart, Jr., R. L., Weinstock, R. S., Ploutz-Snyder, L. L., Kanaley, J. A., Carhart, R L Jr
Předmět:	OBESITY HYPERGLYCEMIA BLOOD sugar BODY weight METABOLIC disorders ANTHROPOMETRY ARTERIES BLOOD flow measurement BODY composition COMPARATIVE studies ENERGY metabolism EXERCISE EXERCISE tests HEMODYNAMICS INSULIN VASCULAR resistance RESEARCH methodology MEDICAL cooperation RESEARCH RESEARCH funding EVALUATION research METABOLIC syndrome BODY mass index OXYGEN consumption PATIENT selection EXERCISE tolerance
Zdroj:	European Journal of Applied Physiology; Oct2009, Vol. 107 Issue 3, p299-308, 10p, 4 Charts, 3 Graphs
Abstrakt:	The aim of the study is to determine the effects of short-term high-intensity exercise on arterial function and glucose tolerance in obese individuals with and without the metabolic syndrome (MetSyn). Obese men and women (BMI > 30 kg/m(2); 39-60 years) with and without MetSyn (MetSyn, n = 13; Non-MetSyn, n = 13) participated in exercise training consisting of ten consecutive days of treadmill walking for 1 h/day at 70-75% of peak aerobic capacity. Changes in aerobic capacity, flow-mediated dilation (FMD), and arterial stiffness using central and peripheral pulse wave velocity (PWV) measurements were assessed pre- and post-training. These measurements were obtained fasting and 1-h post-test meal while the subjects were hyperglycemic. Aerobic capacity improved for both groups [Non-MetSyn 24.0 +/- 1.6 vs. 25.1 +/- 1.5 mL/(kg min); MetSyn 25.2 +/- 1.8 vs. 26.2 +/- 1.7 mL/(kg min), P < 0.05]. There was no change in body weight. FMD decreased by ~20% (P < 0.05) for both groups during acute hyperglycemia (MetSyn, n = 11; Non-MetSyn, n = 10), while hyperglycemia increased central PWV and not peripheral PWV. Exercise training did not change FMD in the fasted or challenged state. Central and peripheral PWV were not altered with training for either group (MetSyn, n = 13; Non-MetSyn, n = 13). A 10-day high-intensity exercise program in obese individuals improved aerobic capacity and glucose tolerance but no change in arterial function was observed. Acute hyperglycemia had a deleterious effect on arterial function, suggesting that persons with impaired glucose homeostasis may experience more opportunities for attenuated arterial function on a daily basis which could contribute to increased cardiovascular risk. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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