| Autor: |
Dinh, Thanh, Doupis, John, Lyons, Thomas E., Kuchibhotla, Sarada, Julliard, Walker, Gnardellis, Charalambos, Rosenblum, Barry I., Wang, Xiaoen, Giurini, John M., Greenman, Robert L., Veves, Aristidis |
| Předmět: |
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| Zdroj: |
Diabetes Care; Aug2009, Vol. 32 Issue 8, p1521-1524, 4p, 1 Graph |
| Abstrakt: |
OBJECTIVE-- To investigate changes in the foot muscle energy reserves in diabetic non-neuropathic and neuropathic patients. RESEARCH DESIGN AND METHODS-- We measured the phosphocreatinine (PCr)/ inorganic phosphate (Pi) ratio, total [sup 31]p concentration, and the lipid/water ratio in the muscles in the metatarsal head region using MRI spectroscopy in healthy control subjects and nonneuropathic and neuropathic diabetic patients. RESULTS -- The PCr/Pi ratio was higher in the control subjects (3.23 ± 0.43) followed by the non-neuropathic group (2.61 ± 0.36), whereas it was lowest in the neuropathic group (0.60 ± 1.02) (P < 0.0001). There were no differences in total [sup 31]p concentration and lipid/water ratio between the control and non-neuropathic groups, but both measurements were different in the neuropathic group (P < 0.0001). CONCLUSIONS -- Resting foot muscle energy reserves are affected before the development of peripheral diabetic neuropathy and are associated with the endothelial dysfunction and inflammation. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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